RESTORE Publications

The first publication from the RESTORE Clinical Trial was released January 2015.

Recent News

Penn Study Suggests Balancing Sedation in Pediatric Patients; 2015

Penn Study: Children with Respiratory Failure Can be Awake Yet Comfortable in the ICU; 2015
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Society of Critical Care Medicine iCritical Care Podcast

Publications
Schneider JB, Sweberg T, Asaro LA, Kirby A, Wypij D, Thiagarajan RR, Curley MAQ. Sedation Management in Children Supported on Extracorporeal Membrane Oxygenation for Acute Respiratory Failure. Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. Crit Care Med. 2017 Oct;45(10): e1001-e1010. PMID: 28614197
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Lebet R, Hayakawa J, Chamblee TB, Tala JA, Singh N, Wypij D, Curley MAQ. Maintaining Interrater Agreement of Core Assessment Instruments in a Multisite Randomized Controlled Clinical Trial: The Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Trial. Nurs Res. 2017 Jul/Aug;66(4):323-329. PMID: 28654569

Natale JE, Lebet R, Joseph JG, Ulysse C, Ascenzi J, Wypij D, Curley MAQ. Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial. Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. J Pediatr. 2017 May; 184:204-208.e1. doi: 10.1016/j.jpeds.2017.02.006. Epub 2017 Mar 2. PMID:  28410087

Weiss SL, Asaro LA, Flori HR, Allen GL, Wypij D, Curley MA. Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure. Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. Pediatr Crit Care Med. 2017 Apr;18(4):319-329. PMID:  28212163

Faustino EV, Gedeit R, Schwarz AJ, Asaro LA, Wypij D, Curley MA. Accuracy of an Extubation Readiness Test in Predicting Successful Extubation in Children With Acute Respiratory Failure From Lower Respiratory Tract Disease. Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. Crit Care Med. 2017 Jan; 45(1):94-102. PMID: 27632676
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Curley, M. A., et al. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. Jama. 2015 Jan; 313(4): 379-389. PMID: 25602358

Grant, M.C., Balas, M.C., Curley, M.A.Q. Defining sedation-related adverse events in the pediatric intensive care unit. Heart & Lung. 2013 May-June; 42(3): 171-176. PMID: 23643411

Grant, M.J.C., Scoppettuolo, L.A., Wypij, D. Curley, M.A.Q. Prospective evaluation of sedation-related adverse events in pediatric patients ventilated for acute respiratory failure. Critical Care Medicine. 2012 April; 40(4): 1317–1323. PMID: 22425823

Franck, L.S., Scoppettuolo, L.A., Wypij, D. Curley, M.A.Q. (2012). Validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) for monitoring iatrogenic withdrawal syndrome in pediatric patients. Pain. 2012 Jan; 153(1): 142–148. PMID: 22093817